Media type: E-Article Title: Clinical trials in gastric cancer and the future Contributor: Mihaljevic, André L.; Friess, Helmut; Schuhmacher, Christoph imprint: Wiley, 2013 Published in: Journal of Surgical Oncology Language: English DOI: 10.1002/jso.23120 ISSN: 0022-4790; 1096-9098 Keywords: Oncology ; General Medicine ; Surgery Origination: Footnote: Description: <jats:title>Abstract</jats:title><jats:p>Following the first successful gastric resection for gastric cancer by Theodor Billroth in 1881 surgery has made tremendous progress leading to improved surgical mortality and morbidity. However, while treatment of early gastric cancer is frequently curative, 5‐year survival rates for advanced gastric cancer remain dismal despite the application of perioperative multimodal treatment concepts. In this article we will outline key clinical trials that have lead to an improvement in treatment of gastric cancer patients with specific emphasis on the last 20 years. We will then outline recent concepts and key clinical trials that are currently being conducted in the field. Finally we will outline open questions that remain to be elucidated in the future. J. Surg. Oncol. 2013;107:289–297. © 2012 Wiley Periodicals, Inc.</jats:p>