Media type: E-Article Title: Toxicokinetics and recovery studies of dicamba dimethyl amine salt in goats following single oral administration Contributor: Mukherjee, Madhusudan; Muraleedharannair, Prashant; Karmakar, Utpal K; Datta, Bakul K; Sar, Tapas K; Chakraborty, Animesh K; Bhattacharya, Anjan; Choudhury, Ashim; Mandal, Tapan K imprint: Wiley, 2010 Published in: Journal of the Science of Food and Agriculture Language: English DOI: 10.1002/jsfa.3806 ISSN: 0022-5142; 1097-0010 Keywords: Nutrition and Dietetics ; Agronomy and Crop Science ; Food Science ; Biotechnology Origination: Footnote: Description: <jats:title>Abstract</jats:title><jats:p><jats:bold>BACKGROUND:</jats:bold> Toxicokinetics and recovery studies of dicamba dimethyl amine salt (DDAS) were conducted to obtain more information about its toxicity and tissue retention in farm animals.</jats:p><jats:p><jats:bold>RESULTS:</jats:bold> The minimum oral toxic dose level of DDAS was determined as 1400 mg kg<jats:sup>−1</jats:sup> body weight. In the toxicokinetic study, blood DDAS concentration of 55.6 ± 0.59 µg mL<jats:sup>−1</jats:sup> (mean ± standard error) was detected at 0.08 h, which peaked to 102.3 ± 5.03 µg mL<jats:sup>−1</jats:sup> at 0.25 h, and declined to a minimum of 4.1 ± 0.06 µg mL<jats:sup>−1</jats:sup> at 36 h. In recovery studies, DDAS concentration in urine began to increase significantly (<jats:italic>P</jats:italic> < 0.05) from 12 h, peaked at 24 h and declined from 48 h onwards. Maximum excretion through faeces was at 24 h and was complete by 144 h. The residual level in tissues decreased significantly (<jats:italic>P</jats:italic> < 0.05) on day 7 as compared to day 4. In histopathological studies, cellular alterations in lungs, liver, kidney, adrenal gland and spleen were found.</jats:p><jats:p><jats:bold>CONCLUSION:</jats:bold> DDAS persists in the body for a shorter period and its major excretory route is through urine. DDAS has lower affinity to accumulate in tissues, and intensity of cellular alterations is not severe after single‐dose oral administration. Copyright © 2009 Society of Chemical Industry</jats:p>