Media type: E-Article Title: Diagnostic considerations in juvenile parkinsonism Contributor: Paviour, Dominic C.; Surtees, Robert A.H.; Lees, Andrew J. Published: Wiley, 2004 Published in: Movement Disorders, 19 (2004) 2, Seite 123-135 Language: English DOI: 10.1002/mds.10644 ISSN: 0885-3185; 1531-8257 Origination: Footnote: Description: AbstractJuvenile parkinsonism (JP) describes patients in whom the clinical features of parkinsonism manifest before 21 years of age. Many reported cases that had a good response to levodopa have proved to have autosomal recessive juvenile parkinsonism (AR‐JP) due to mutations in the parkin gene. With the exception of parkin mutations and dopa‐responsive dystonia, most causes are associated with the presence of additional neurological signs, resulting from additional lesions outside of the basal ganglia. Lewy body pathology has only been reported in one case, suggesting that a juvenile form of idiopathic Parkinson's disease may be extremely rare. © 2003 Movement Disorder Society