Media type: E-Article Title: Ten‐Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease Contributor: Timmermann, Lars; Wojtecki, Lars; Gross, Joachim; Lehrke, Ralph; Voges, Jürgen; Maarouf, Mohammed; Treuer, Harald; Sturm, Volker; Schnitzler, Alfons imprint: Wiley, 2004 Published in: Movement Disorders Language: English DOI: 10.1002/mds.20198 ISSN: 1531-8257; 0885-3185 Origination: Footnote: Description: <jats:title>Abstract</jats:title><jats:p>Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation (≥130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD. © 2004 Movement Disorder Society</jats:p>