Media type: E-Article Title: Study of medication‐free children with Tourette syndrome do not show imaging abnormalities Contributor: Jeppesen, Signe Søndergaard; Debes, Nanette Mol; Simonsen, Helle Juhl; Rostrup, Egill; Larsson, H.B.W.; Skov, Liselotte imprint: Wiley, 2014 Published in: Movement Disorders Language: English DOI: 10.1002/mds.25858 ISSN: 1531-8257; 0885-3185 Keywords: Neurology (clinical) ; Neurology Origination: Footnote: Description: <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Imaging studies of patients with Tourette's syndrome (TS) across different cohorts have shown alterations in gray and white matter in areas associated with the cortico‐striato‐thalamic‐cortical (CSTC) pathways; however, no consistent findings have subsequently established a clear indication of the pathophysiology of TS.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study was designed to investigate changes in gray and white matter in medication‐free children with TS in the CSTC areas. With MRI, 24 children with TS and 18 healthy controls were analyzed using three complementary methods.</jats:p></jats:sec><jats:sec><jats:title>Results and Conclusion</jats:title><jats:p>Analyses revealed no differences between controls and patients with TS in gray or white matter. Possible discrepancies between cohorts and methods may play a role in the different findings in other studies. Further studies investigating well‐defined cohorts with TS analyzing both gray and white matter in the same cohort may add additional information to the pathophysiology of TS. © 2014 International Parkinson and Movement Disorder Society</jats:p></jats:sec>