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Media type:
E-Article
Title:
Cortical myoclonus in huntington's disease associated with an enlarged somatosensory evoked potential
Contributor:
Caviness, John N;
Kurth, Mathias
imprint:
Wiley, 1997
Published in:Movement Disorders
Language:
English
DOI:
10.1002/mds.870120633
ISSN:
0885-3185;
1531-8257
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:p>We report the electrophysiologic findings of myoclonus in a patient with Huntington's disease (HD). This patient was studied postoperatively after a bilateral fetal cell transplant in his striatum. Incomplete transient improvement was seen in the myoclonus, followed by gradual deterioration. The myoclonus itself had a cortical correlate and was associated with an enlarged somatosensory evoked potential (SEP), consistent with the presence of cortical reflex myoclonus. An enlarged SEP has not been previously reported in myoclonus associated with HD. The postulated mechanisms for myoclonus, when it occurs in HD, have differed in the literature. The reason for the transient improvement of the myoclonus following transplantation is unclear, but this case raises the possibility that basal ganglia circuits may modulate cortical myoclonic activity.</jats:p>