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Gutiérrez‐Repiso, Carolina; Hernández‐García, Carmen; García‐Almeida, José Manuel; Bellido, Diego; Martín‐Núñez, Gracia María; Sánchez‐Alcoholado, Lidia; Alcaide‐Torres, Juan; Sajoux, Ignacio; Tinahones, Francisco J.; Moreno‐Indias, Isabel

Effect of Synbiotic Supplementation in a Very‐Low‐Calorie Ketogenic Diet on Weight Loss Achievement and Gut Microbiota: A Randomized Controlled Pilot Study

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  • Media type: E-Article
  • Title: Effect of Synbiotic Supplementation in a Very‐Low‐Calorie Ketogenic Diet on Weight Loss Achievement and Gut Microbiota: A Randomized Controlled Pilot Study
  • Contributor: Gutiérrez‐Repiso, Carolina; Hernández‐García, Carmen; García‐Almeida, José Manuel; Bellido, Diego; Martín‐Núñez, Gracia María; Sánchez‐Alcoholado, Lidia; Alcaide‐Torres, Juan; Sajoux, Ignacio; Tinahones, Francisco J.; Moreno‐Indias, Isabel
  • imprint: Wiley, 2019
  • Published in: Molecular Nutrition & Food Research
  • Language: English
  • DOI: 10.1002/mnfr.201900167
  • ISSN: 1613-4125; 1613-4133
  • Keywords: Food Science ; Biotechnology
  • Origination:
  • Footnote:
  • Description: <jats:sec><jats:title>Scope</jats:title><jats:p>Little is known about the changes that a very‐low‐calorie ketogenic diet (VLCKD) produces in gut microbiota or the effect of synbiotics during the diet. The aim of this study is to evaluate changes in gut microbiota produced by a VLCKD and synbiotic supplementation.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>A randomized, single‐blind, parallel‐design trial is conducted in 33 obese patients who follow a weight‐loss program (PnK‐Method) that include a VLCKD followed by a low‐calorie diet (LCD). Subjects are randomly allocated to three groups: one supplemented with synbiotics, a second group supplemented with a placebo during the VLCKD and synbiotics during the LCD phase, and a control group given a placebo.</jats:p><jats:p>Although symbiotic administration do not produce an effect on microbial diversity, an increase in short‐chain fatty aciding producing bacteria and anti‐inflammatory mediator signals such as <jats:italic>Odoribacter</jats:italic> and <jats:italic>Lachnospira</jats:italic> is shown. The administration of <jats:italic>Bifidobacterium animalis subsp. lactis</jats:italic> and prebiotics fiber during the LCD is significantly associated with the percentage of weight loss and change in glucose, C‐reactive protein and lipopolysaccharide‐binding protein.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>VLCKD produces important changes in gut microbiota. The administration of synbiotics during VLCKD can improve weight loss through the amelioration of inflammation, which may be mediated by the gut microbiota.</jats:p></jats:sec>