Media type: E-Article Title: Development of hypertension in neuroblastoma during therapy: A case report Contributor: Wolff, Johannes E. A.; Bauch, Hans Jochen; Roessner, Albert; Boos, Joachim; Gressner‐Brocks, Veronika; Ritter, Jörg; Jürgens, Herbert Published: Wiley, 1993 Published in: Medical and Pediatric Oncology, 21 (1993) 6, Seite 460-464 Language: English DOI: 10.1002/mpo.2950210615 ISSN: 0098-1532; 1096-911X Origination: Footnote: Description: AbstractA case of stage 4 neuroblastoma that developed excessive hypertension on day 120 of chemotherapy is presented. The tumor initially had responded well to chemotherapy; however, while the tumor mass decreased, plasma and urine catecholamines and the blood pressure increased. The plasma concentrations of noradrenaline, adrenaline, and dopamine increased to 26.4, 1.8, and 36.2 μg/l, respectively. The profile of catecholamine metabolites changed: on day 150 of therapy, noradrenaline, adrenaline, and dopamine levels were increased, whereas HVA and VMA levels were decreased when compared to day 1 of therapy. The only residual neuroblastoma tissue visible on MIBG scintigraphy on day 150 of treatment was a metastasis in the left tibia which was irradiated with 24 Gy. The adrenaline concentration in the left femoral vein was twice as high compared to the right femoral vein. A treatment, possibly radiation‐associated tumor cell alteration resulting in a different catecholamine production, is discussed. © 1993 Wiley‐Liss, Inc.