Media type: E-Article Title: High‐dose consolidation with local radiation and bone marrow rescue in patients with advanced neuroblastoma Contributor: Kremens, Bernhard; Klingebiel, Thomas; Herrmann, Friedrich; Bender‐Götze, Christine; Burdach, Stefan; Ebell, Wolfram; Friedrich, Wolfgang; Koscielniak, Ewa; Schmid, Hansjörg; Siegert, Wolfgang; Suttorp, Meinolf; Schaefer, Ulrich W.; Berthold, Frank Published: Wiley, 1994 Published in: Medical and Pediatric Oncology, 23 (1994) 6, Seite 470-475 Language: English DOI: 10.1002/mpo.2950230604 ISSN: 0098-1532; 1096-911X Keywords: Cancer Research ; Oncology ; Pediatrics, Perinatology and Child Health Origination: Footnote: Description: AbstractTwenty‐six children with advanced neuroblastoma were consolidated with cisplatin, BCNU, etoposide, melphalan, 21 Gy of local radiotherapy, and bone marrow rescue in a multicenter study. All patients were over 1 year of age at diagnosis. Twenty‐two patients were treated in first complete or partial remission and four in second complete or partial remission. Hematologic rescue was autologous (n = 23), allogeneic (n = 2), or syngeneic (n = 1). Extrahematological toxicity involved primarily the gastrointestinal mucosa. Among five fatal toxicities, three included intestinal hemorrhage. Fourteen patients relapsed after BMT, four of them at the primary site. Seven children survive progression‐free after 16–56 months.These results are essentially not different from a single‐center study with the same protocol or from other published studies. The value of megatherapy for patients with advanced neuroblastoma or for a subgroup of them can only be established on a larger number of patients than most national trials accrue. © 1994 Wiley‐Liss, Inc.