Media type: E-Article Title: Model‐free arterial spin labeling quantification approach for perfusion MRI Contributor: Petersen, Esben Thade; Lim, Tchoyoson; Golay, Xavier Published: Wiley, 2006 Published in: Magnetic Resonance in Medicine, 55 (2006) 2, Seite 219-232 Language: English DOI: 10.1002/mrm.20784 ISSN: 0740-3194; 1522-2594 Origination: Footnote: Description: AbstractIn this work a model‐free arterial spin labeling (ASL) quantification approach for measuring cerebral blood flow (CBF) and arterial blood volume (aBV) is proposed. The method is based on the acquisition of a train of multiple images following the labeling scheme. Perfusion is obtained using deconvolution in a manner similar to that of dynamic susceptibility contrast (DSC) MRI. Local arterial input functions (AIFs) can be estimated by subtracting two perfusion‐weighted images acquired with and without crusher gradients, respectively. Furthermore, by knowing the duration of the bolus of tagged arterial blood, one can estimate the aBV on a voxel‐by‐voxel basis. The maximum of the residue function obtained from the deconvolution of the tissue curve by the AIF is a measure of CBF after scaling by the locally estimated aBV. This method provides averaged gray matter (GM) perfusion values of 38 ± 2 ml/min/100 g and aBV of 0.93% ± 0.06%. The average CBF value is 10% smaller than that obtained on the same data set using the standard general kinetic model (42 ± 2 ml/min/100 g). Monte Carlo simulations were performed to compare this new methodology with parametric fitting by the conventional model. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.