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Recasens, Bernat Bertran; Balañá Corberó, Ana; Llorens, Juana María Martínez; Guillen‐Sola, Anna; Moreno, Montserrat Villatoro; Escobar, Greta García; Umayahara, Yasutaka; Soh, Zu; Tsuji, Toshio; Rubio, Miguel Ángel

Sound‐based cough peak flow estimation in patients with neuromuscular disorders

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  • Media type: E-Article
  • Title: Sound‐based cough peak flow estimation in patients with neuromuscular disorders
  • Contributor: Recasens, Bernat Bertran; Balañá Corberó, Ana; Llorens, Juana María Martínez; Guillen‐Sola, Anna; Moreno, Montserrat Villatoro; Escobar, Greta García; Umayahara, Yasutaka; Soh, Zu; Tsuji, Toshio; Rubio, Miguel Ángel
  • imprint: Wiley, 2024
  • Published in: Muscle & Nerve
  • Language: English
  • DOI: 10.1002/mus.27987
  • ISSN: 0148-639X; 1097-4598
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction/Aims</jats:title><jats:p>Cough impairment is common in individuals with neuromuscular disorders and is associated with respiratory infections and shorter survival. Cough strength is assessed by measuring cough peak flow (CPF) using a flow meter, but this method requires a complex device setup and trained staff. The aim of the study is to evaluate the reliability of a smartphone app to estimate CPF based on cough sounds in a cohort of individuals with neuromuscular disorders.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Individuals with neuromuscular disorders underwent CPF measurement with a flow meter and a smartphone app. A CPF &lt;270 L/min was considered abnormal.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of the 50 patients studied, 26 had amyotrophic lateral sclerosis (52%), 15 had hereditary myopathies (30%), and 9 had myasthenia gravis (18%). The intraclass correlation coefficient (ICC) between the CPF measured with a flow meter and CPF estimated with cough sounds was 0.774 (<jats:italic>p</jats:italic> &lt; .001) even if the patients had orofacial weakness (ICC = 0.806, <jats:italic>p</jats:italic> &lt; .001). The smartphone app had 94.4% sensitivity and 100% specificity to detect patients with CPF of less than 270 L/min.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Our findings suggest that sounds measured with a smartphone app provide a reliable estimate of CPF in patients with neuromuscular disorders, even in the presence of with orofacial weakness. This may be a convenient way to monitor respiratory involvement in patients with neuromuscular disorders, but larger studies of more diverse patient cohorts are needed.</jats:p></jats:sec>