Bakels, Victor;
Van Oostveen, Johan W.;
Geerts, Marie‐Louise;
Gordin, Roel L. J.;
Walboomers, Jan M. M.;
Scheffer, Erik;
Meijer, Chris J. L. M.;
Willemze, Rein
Diagnostic and prognostic significance of clonal T‐cell receptor beta gene rearrangements in lymph nodes of patients with mycosis fungoides
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Media type:
E-Article
Title:
Diagnostic and prognostic significance of clonal T‐cell receptor beta gene rearrangements in lymph nodes of patients with mycosis fungoides
Contributor:
Bakels, Victor;
Van Oostveen, Johan W.;
Geerts, Marie‐Louise;
Gordin, Roel L. J.;
Walboomers, Jan M. M.;
Scheffer, Erik;
Meijer, Chris J. L. M.;
Willemze, Rein
Published:
Wiley, 1993
Published in:
The Journal of Pathology, 170 (1993) 3, Seite 249-255
Description:
AbstractIn this study, 25 involved and uninvolved lymph nodes from 22 patients with mycosis fungoides (MF) and seven dermatopathic lymph nodes from patients with benign skin disorders were studied for the presence of clonal T‐cell receptor beta (TCRβ) gene rearrangements by Southern blot analysis. These results were correlated with the histological classification, follow‐up data, and survival. The results of the histological classification and Southern blot analysis were concordant in 26 of 32 cases. Clonal TCRβ gene rearrangements were found in all six MF lymph nodes showing (partial) effacement of the normal lymph node architecture, but in none of the eight uninvolved dermatopathic MF lymph nodes and in none of the seven dermatopathic control lymph nodes. In addition, in 5 of 11 dermatopathic MF lymph nodes that were considered to have early involvement by MF at histological examination, clonal TCRβ gene rearrangements were detected. In the group of MF patients with dermatopathic lymphadenopathy, patients with detectable clonal T‐cell populations had a significantly shorter survival than patients without such a population (P<0.01). The results of this study indicate that within the group of dermatopathic MF lymph nodes, prognostically different groups can be distinguished and that TCRβ gene rearrangement analysis may be an important adjunct in the early diagnosis of lymph node involvement by MF.