• Media type: E-Article
  • Title: Prenatal diagnosis and clinical implications of an apparently isolated right aortic arch
  • Contributor: Vigneswaran, Trisha V.; Allan, Lindsey; Charakida, Marietta; Durward, Andrew; Simpson, John M.; Nicolaides, Kypros H.; Zidere, Vita
  • imprint: Wiley, 2018
  • Published in: Prenatal Diagnosis
  • Language: English
  • DOI: 10.1002/pd.5388
  • ISSN: 0197-3851; 1097-0223
  • Keywords: Genetics (clinical) ; Obstetrics and Gynecology
  • Origination:
  • Footnote:
  • Description: <jats:p>What is already known about the topic? <jats:list list-type="bullet"> <jats:list-item><jats:p>Right aortic arch (RAA) has an association with extracardiac and chromosomal anomalies.</jats:p></jats:list-item> <jats:list-item><jats:p>RAA with left arterial duct can form a vascular ring.</jats:p></jats:list-item> <jats:list-item><jats:p>In children with RAA, there is poor correlation of symptoms and tracheal compression.</jats:p></jats:list-item> </jats:list></jats:p><jats:p>What does this study add? <jats:list list-type="bullet"> <jats:list-item><jats:p>The majority of prenatal cases of an isolated RAA in our cohort are identified during routine screening.</jats:p></jats:list-item> <jats:list-item><jats:p>Microdeletion of chromosome 22q11 is the most common genetic association with an apparently isolated RAA, it is seen in a minimum of 7% of cases.</jats:p></jats:list-item> <jats:list-item><jats:p>A chromosomal or genetic anomaly is found in half of fetuses with RAA and increased nuchal translucency thickness (NT) and in one‐fifth of those with normal NT.</jats:p></jats:list-item> </jats:list></jats:p>