Media type: E-Article Title: Prevalence, prenatal diagnosis and survival of gastroschisis Contributor: Fillingham, Anna; Rankin, Judith imprint: Wiley, 2008 Published in: Prenatal Diagnosis Language: English DOI: 10.1002/pd.2153 ISSN: 0197-3851; 1097-0223 Keywords: Genetics (clinical) ; Obstetrics and Gynecology Origination: Footnote: Description: <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To describe the prevalence, associated anomalies, prenatal diagnosis and survival of cases of gastroschisis.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>Data were extracted from the Northern Congenital Abnormality Survey (NorCAS) for cases delivered during 1997 to 2006.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 143 cases of gastroschisis were notified from 310 410 registered births. Ten (7%) gastroschisis cases were associated with other structural anomalies. The male to female ratio among isolated gastroschisis cases was 1:1.1 and 4:1 among non‐isolated cases. The total prevalence for isolated cases was 4.28 per 10 000 births (95% CI 3.56–5.01), and the overall live birth prevalence was 4.21 per 10 000 live births (95% CI 3.49–4.93). There was an increase in total prevalence during the ten years, although this increase did not reach statistical significance (χ<jats:sup>2</jats:sup> test for trend = 0.996, p = 0.318). The maternal age‐specific prevalence was highest in the less than 20 years age group (18.6 per 10 000 births (95% CI 14.0–23.3)). 130 (97.7%) isolated cases resulted in a live birth; 122 (91.7%) infants were alive at age one year. The accuracy of prenatal diagnosis was high, with gastroschisis being detected in 130 (97.7%) isolated cases.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>This population‐based study demonstrates a continued increase in gastroschisis, especially in young mothers. The accuracy of prenatal diagnosis was very high. Just over 90% of children born with gastroschisis survived. Copyright © 2008 John Wiley & Sons, Ltd.</jats:p></jats:sec>