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Media type:
E-Article
Title:
On the excessive use of coefficient of variation as a metric of quantitation quality in proteomics
Contributor:
Ivanov, Mark V.;
Garibova, Leyla A.;
Postoenko, Valeriy I.;
Levitsky, Lev I.;
Gorshkov, Mikhail V.
imprint:
Wiley, 2024
Published in:PROTEOMICS
Language:
English
DOI:
10.1002/pmic.202300090
ISSN:
1615-9853;
1615-9861
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:p>The coefficient of variation (CV) is often used in proteomics as a proxy to characterize the performance of a quantitation method and/or the related software. In this note, we question the excessive reliance on this metric in quantitative proteomics that may result in erroneous conclusions. We support this note using a ground‐truth Human‐Yeast‐<jats:italic>E. coli</jats:italic> dataset demonstrating in a number of cases that erroneous data processing methods may lead to a low CV which has nothing to do with these methods’ performances in quantitation.</jats:p>