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Media type:
E-Article
Title:
Synthese von Halogenacetyl‐ und Chlorambucil‐Peptiden des Eledoisins, Physalaemins und der Substanz P als potentielle Affinitätsmarker
Contributor:
Bienert, M.;
Mehlis, B.;
Kühler, M.;
Bergmann, J.;
Niedrich, H.
imprint:
Wiley, 1978
Published in:Journal für Praktische Chemie
Language:
English
DOI:
10.1002/prac.19783200213
ISSN:
0021-8383
Origination:
Footnote:
Description:
<jats:p><jats:bold>Synthesis of Halogenacetyl‐ and Chlorambucil Substituted Peptides of Eledoisin, Physalaemin and Substance P for Affinity Labeling</jats:bold></jats:p><jats:p>Partial sequences of eledoisin have been synthesized in a stepwise manner using Boc‐aminoacid‐2,4,5‐trichlorophenyl esters. These sequences and partial sequences of physalaemin and substance P were acylated via trichloro — or pentachlorophenyl esters and mixed anhydrides of bromo — and iodoacetic acid. Two eledoisin sequences have been prepared which bear a chlorambucil group. A irreversible binding of these potential affinity labels to the isolated guinea pig ileum was not observed.</jats:p>