Media type: E-Article Title: Substituted α‐(phenylhydrazono)phenylacetonitrile derivatives. Part 2: synthesis and biological activity of pro‐pesticides Contributor: Flury, Thomas; Hall, Roger G; Karrer, Friedrich; Kienast, Heinz; Leuenberger, Katrin; Pascual, Alfons; Rindlisbacher, Alfred; Trah, Stephan; Widmer, Hans‐Joerg imprint: Wiley, 2006 Published in: Pest Management Science Language: English DOI: 10.1002/ps.1166 ISSN: 1526-498X; 1526-4998 Keywords: Insect Science ; Agronomy and Crop Science ; General Medicine Origination: Footnote: Description: <jats:title>Abstract</jats:title><jats:p>Pro‐pesticides of α‐(2,6‐dichloro‐4‐trifluoromethylphenylhydrazono)‐4‐nitrophenylacetonitrile have been prepared and tested against mite and insect pests. Variations in potency and spectrum were observed depending on the choice of cleavable pro‐moiety. Cleavage of the pro‐moiety was demonstrated in one case by measuring the rate of increase in the uncoupling activity using a mitochondrial preparation. Irradiation experiments have demonstrated a rapid isomerisation of the planar <jats:italic>Z</jats:italic> isomer to the <jats:italic>E</jats:italic> isomer, which is reversible. Copyright © 2006 Society of Chemical Industry</jats:p>