Media type: E-Article Title: Antiulcerogenic Activities of the Extracts and Isolated Flavonoids of Euphorbia cuneata Vahl Contributor: Awaad, Amani S.; Al‐Jaber, Nabilah A.; Moses, John E.; El‐Meligy, Reham M.; Zain, Mohamed E Published: Wiley, 2013 Published in: Phytotherapy Research, 27 (2013) 1, Seite 126-130 Language: English DOI: 10.1002/ptr.4872 ISSN: 0951-418X; 1099-1573 Origination: Footnote: Description: <jats:p>The total alcohol extracts of <jats:italic>Euphorbia cuneata</jats:italic> Vahl.(Euphorbiaceae) were screened for antiulcerogenic activity using an ethanol‐induced ulcer model at doses of 125, 250 and 500 mg/kg. The extracts possessed antiulcerogenic activity in a dose‐dependent manner. Four flavonoidal compounds were isolated and identified as naringenin, aromadendrin, apigenin and 4'‐<jats:italic>O</jats:italic>‐methoxy‐luteolin‐7‐<jats:italic>O</jats:italic>‐rhamnoglucoside, each demonstrating antiulcerogenic activity with curative ratios ranging from 75.78% to 88.23%. In addition, the alcohol extracts and isolated compounds were shown to scavenge the 1,1‐diphenyl,2‐picrylhydrazyl radical by different ratio, with the most effective being 4'‐<jats:italic>O</jats:italic>‐methoxy‐luteolin‐7‐<jats:italic>O</jats:italic>‐rhamnoglucoside (91.14%). The antioxidant activity of the alcohol extracts and the isolated compounds may explain the antiulcerogenic properties. No side effects were observed on either liver or kidney functions. Copyright © 2012 John Wiley & Sons, Ltd.</jats:p>