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Media type:
E-Article
Title:
Neural crest-like stem cells for tissue regeneration
Contributor:
Soto, Jennifer;
Ding, Xili;
Wang, Aijun;
Li, Song
Published:
Oxford University Press (OUP), 2021
Published in:
Stem Cells Translational Medicine, 10 (2021) 5, Seite 681-693
Language:
English
DOI:
10.1002/sctm.20-0361
ISSN:
2157-6564;
2157-6580
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title>
<jats:p>Neural crest stem cells (NCSCs) are a transient population of cells that arise during early vertebrate development and harbor stem cell properties, such as self-renewal and multipotency. These cells form at the interface of non-neuronal ectoderm and neural tube and undergo extensive migration whereupon they contribute to a diverse array of cell and tissue derivatives, ranging from craniofacial tissues to cells of the peripheral nervous system. Neural crest-like stem cells (NCLSCs) can be derived from pluripotent stem cells, placental tissues, adult tissues, and somatic cell reprogramming. NCLSCs have a differentiation capability similar to NCSCs, and possess great potential for regenerative medicine applications. In this review, we present recent developments on the various approaches to derive NCLSCs and the therapeutic application of these cells for tissue regeneration.</jats:p>