Description:
<jats:title>Abstract</jats:title><jats:p>The structure analysis, antioxidant activity in vitro, and organ repair evaluation of <jats:italic>Pholiota adiposa</jats:italic> residue polysaccharides (PRP) on <jats:sc>d</jats:sc>‐galactose‐induced aging mice in this work are carried out. The structural results show that PRP contains β glycoside bonded pyranose and is mainly composed of mannose glucose and galactose. The in vitro antioxidant assay demonstrates that PRP has superior reducing power and scavenging activities on hydroxyl, superoxide anion and DPPH radicals. The in vivo animal experiments confirmed that PRP can effectively increase organ index, reduce the levels of IL‐6 and TNF‐α and the contents of ALT, AST, ALP, CREA, and UA in serum induced by <jats:sc>d</jats:sc>‐galactose. It can significantly increase the content of HYP in skin. Meanwhile, the activities of SOD, GSH‐PX, and CAT are improved and the accumulation of MDA is reduced by repairing the structure and function of the damaged liver, kidney, and brain. These results demonstrate that PRP have certain organ protection effects on <jats:sc>d</jats:sc>‐galactose‐induced aging mice, indicating that it has potential application values in functional anti‐aging food and natural medicine.</jats:p>