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Greten, Stephan; Wegner, Florian; Jensen, Ida; Krey, Lea; Rogozinski, Sophia; Fehring, Meret; Heine, Johanne; Doll-Lee, Johanna; Pötter-Nerger, Monika; Zeitzschel, Molly; Hagena, Keno; Pedrosa, David J.; Eggers, Carsten; Bürk, Katrin; Trenkwalder, Claudia; Claus, Inga; Warnecke, Tobias; Süß, Patrick; Winkler, Jürgen; Gruber, Doreen; Gandor, Florin; Berg, Daniela; Paschen, Steffen; Classen, Joseph; [...]

The comorbidity and co-medication profile of patients with progressive supranuclear palsy

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  • Media type: E-Article
  • Title: The comorbidity and co-medication profile of patients with progressive supranuclear palsy
  • Contributor: Greten, Stephan; Wegner, Florian; Jensen, Ida; Krey, Lea; Rogozinski, Sophia; Fehring, Meret; Heine, Johanne; Doll-Lee, Johanna; Pötter-Nerger, Monika; Zeitzschel, Molly; Hagena, Keno; Pedrosa, David J.; Eggers, Carsten; Bürk, Katrin; Trenkwalder, Claudia; Claus, Inga; Warnecke, Tobias; Süß, Patrick; Winkler, Jürgen; Gruber, Doreen; Gandor, Florin; Berg, Daniela; Paschen, Steffen; Classen, Joseph; [...]
  • imprint: Springer Science and Business Media LLC, 2024
  • Published in: Journal of Neurology
  • Language: English
  • DOI: 10.1007/s00415-023-12006-4
  • ISSN: 0340-5354; 1432-1459
  • Keywords: Neurology (clinical) ; Neurology
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Progressive supranuclear palsy (PSP) is usually diagnosed in elderly. Currently, little is known about comorbidities and the co-medication in these patients.</jats:p> </jats:sec><jats:sec> <jats:title>Objectives</jats:title> <jats:p>To explore the pattern of comorbidities and co-medication in PSP patients according to the known different phenotypes and in comparison with patients without neurodegenerative disease.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Cross-sectional data of PSP and patients without neurodegenerative diseases (non-ND) were collected from three German multicenter observational studies (DescribePSP, ProPSP and DANCER). The prevalence of comorbidities according to WHO ICD-10 classification and the prevalence of drugs administered according to WHO ATC system were analyzed. Potential drug–drug interactions were evaluated using AiD<jats:italic>Klinik</jats:italic>®.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>In total, 335 PSP and 275 non-ND patients were included in this analysis. The prevalence of diseases of the circulatory and the nervous system was higher in PSP at first level of ICD-10. Dorsopathies, diabetes mellitus, other nutritional deficiencies and polyneuropathies were more frequent in PSP at second level of ICD-10. In particular, the summed prevalence of cardiovascular and cerebrovascular diseases was higher in PSP patients. More drugs were administered in the PSP group leading to a greater percentage of patients with polypharmacy. Accordingly, the prevalence of potential drug–drug interactions was higher in PSP patients, especially severe and moderate interactions.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>PSP patients possess a characteristic profile of comorbidities, particularly diabetes and cardiovascular diseases. The eminent burden of comorbidities and resulting polypharmacy should be carefully considered when treating PSP patients.</jats:p> </jats:sec>