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Ramos-Rincon, Jose-Manuel; Torrús-Tendero, Diego; García-Morante, Hilarion; Gimeno-Gascón, Adelina; Marco, Francisco; Gil-Anguita, Concepción; Wikman-Jorgensen, Philip; Lucas-Dato, Ana; Rodriguez-Diaz, Juan-Carlos; Amador, Concepción; Llenas-García, Jara

Cytokine profile levels and their relationship with parasitemia and cardiomyopathy in people with Chagas disease in Spain. A prospective observational study

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  • Media type: E-Article
  • Title: Cytokine profile levels and their relationship with parasitemia and cardiomyopathy in people with Chagas disease in Spain. A prospective observational study
  • Contributor: Ramos-Rincon, Jose-Manuel; Torrús-Tendero, Diego; García-Morante, Hilarion; Gimeno-Gascón, Adelina; Marco, Francisco; Gil-Anguita, Concepción; Wikman-Jorgensen, Philip; Lucas-Dato, Ana; Rodriguez-Diaz, Juan-Carlos; Amador, Concepción; Llenas-García, Jara
  • imprint: Springer Science and Business Media LLC, 2024
  • Published in: Parasitology Research
  • Language: English
  • DOI: 10.1007/s00436-023-08042-8
  • ISSN: 0932-0113; 1432-1955
  • Keywords: Infectious Diseases ; Insect Science ; General Veterinary ; General Medicine ; Parasitology
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Immunoregulatory networks may have a role in controlling parasitemia in the chronic phase of human Chagas disease. The aim was to describe the serum cytokine profile of <jats:italic>Trypanosoma cruzi</jats:italic> in chronically infected patients and to evaluate its relationship with parasitemia and Chagas cardiomyopathy.</jats:p><jats:p>This prospective observational study included adult patients with chronic Chagas disease. Demographic and clinical data were collected, and peripheral blood samples were used to perform <jats:italic>T. cruzi</jats:italic> real-time polymerase chain reaction (RT-PCR) and determine the serum cytokine profile.</jats:p><jats:p>Fifty-eight patients were included; 17 (29.3%) had positive RT-PCR results. This group had a higher median concentration of TNF-α (<jats:italic>p</jats:italic> = 0.003), IL-6 (<jats:italic>p</jats:italic> = 0.021), IL-4 (<jats:italic>p</jats:italic> = 0.031), IL-1β (<jats:italic>p</jats:italic> = 0.036), and IL-17A (<jats:italic>p</jats:italic> = 0.043) than those with a negative RT-PCR. Patients with cardiac involvement had a higher median concentration of IL-5 (<jats:italic>p</jats:italic> = 0.016) than those without<jats:italic>.</jats:italic></jats:p><jats:p>These results reinforce the key role that cytokines play in Chagas disease patients with parasitemia and cardiac involvement.</jats:p>