You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Tick saliva and its role in pathogen transmission
Contributor:
Nuttall, Patricia A.
Published:
Springer Science and Business Media LLC, 2023
Published in:
Wiener klinische Wochenschrift, 135 (2023) 7-8, Seite 165-176
Language:
English
DOI:
10.1007/s00508-019-1500-y
ISSN:
1613-7671;
0043-5325
Origination:
University thesis:
Footnote:
Description:
<jats:title>Summary</jats:title><jats:p>Tick saliva is a complex mixture of peptidic and non-peptidic molecules that aid engorgement. The composition of tick saliva changes as feeding progresses and the tick counters the dynamic host response. Ixodid ticks such as <jats:italic>Ixodes ricinus</jats:italic>, the most important tick species in Europe, transmit numerous pathogens that cause debilitating diseases, e.g. Lyme borreliosis and tick-borne encephalitis. Tick-borne pathogens are transmitted in tick saliva during blood feeding; however, saliva is not simply a medium enabling pathogen transfer. Instead, tick-borne pathogens exploit saliva-induced modulation of host responses to promote their transmission and infection, so-called saliva-assisted transmission (SAT). Characterization of the saliva factors that facilitate SAT is an active area of current research. Besides providing new insights into how tick-borne pathogens survive in nature, the research is opening new avenues for vaccine development.</jats:p>