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Cimino, Matteo Maria; Biloslavo, Alan; Kurihara, Hayato; Bellio, Gabriele; Porta, Matteo; Fattori, Silvia; Bass, Gary Alan; Bass, Gary Alan; Mohseni, Shahin; Kaplan, Lewis J.; Ahl-Hulme, Rebecka; Biloslavo, Alan; Cao, Yang; Forssten, Maximilian Peter; Kurihara, Hayato; Martinez-Casas, Isidro; Pereira, Jorge; Pourlotfi, Arvid; Ryan, Éanna J.; Tolonen, Matti; Louri, Nayef; Nedham, Fatema; Walsh, Thomas Noel; Hashem, Jamal; [...]

Practice patterns and clinical outcomes in acute appendicitis differ in the elderly patient

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  • Media type: E-Article
  • Title: Practice patterns and clinical outcomes in acute appendicitis differ in the elderly patient
  • Contributor: Cimino, Matteo Maria; Biloslavo, Alan; Kurihara, Hayato; Bellio, Gabriele; Porta, Matteo; Fattori, Silvia; Bass, Gary Alan; Bass, Gary Alan; Mohseni, Shahin; Kaplan, Lewis J.; Ahl-Hulme, Rebecka; Biloslavo, Alan; Cao, Yang; Forssten, Maximilian Peter; Kurihara, Hayato; Martinez-Casas, Isidro; Pereira, Jorge; Pourlotfi, Arvid; Ryan, Éanna J.; Tolonen, Matti; Louri, Nayef; Nedham, Fatema; Walsh, Thomas Noel; Hashem, Jamal; [...]
  • Published: Springer Science and Business Media LLC, 2024
  • Published in: European Journal of Trauma and Emergency Surgery (2024)
  • Language: English
  • DOI: 10.1007/s00068-024-02620-w
  • ISSN: 1863-9933; 1863-9941
  • Origination:
  • Footnote:
  • Description: Abstract Background Appendicitis is the most frequent global abdominal surgical emergency. An ageing population, who often exhibit atypical symptoms and delayed presentations, challenge conventional diagnostic and treatment paradigms. Objectives This study aims to delineate disparities in presentation, management, and outcomes between elderly patients and younger adults suffering from acute appendicitis. Methods This subgroup analysis forms part of ESTES SnapAppy, a time-bound multi-center prospective, observational cohort study. It includes patients aged 15 years and above who underwent laparoscopic appendectomy during a defined 90-day observational period across multiple centers. Statistical comparisons were performed using appropriate tests with significance set at p < 0.05. Results The study cohort comprised 521 elderly patients (≥65 years) and 4,092 younger adults (18–64 years). Elderly patients presented later (mean duration of symptoms: 7.88 vs. 3.56 days; p < 0.001) and frequently required computed tomography (CT) scans for diagnosis (86.1% vs. 54.0%; p < 0.001). The incidence of complicated appendicitis was higher in the elderly (46.7% vs. 20.7%; p < 0.001). Delays in surgical intervention were notable in the elderly (85.0% operated within 24 h vs. 88.7%; p = 0.018), with longer operative times (71.1 vs. 60.3 min; p < 0.001). Postoperative complications were significantly higher in the elderly (27.9% vs. 12.9%; p < 0.001), including severe complications (6.9% vs. 2.4%; p < 0.001) and prolonged hospital stays (7.9 vs. 3.6 days; p < 0.001). Conclusions Our findings highlight significant differences in the clinical course and outcomes of acute appendicitis in the elderly compared to younger patients, suggesting a need for age-adapted diagnostic pathways and treatment strategies to improve outcomes in this vulnerable population.