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Albano, Domenico; Bertagna, Francesco; Alongi, Pierpaolo; Baldari, Sergio; Baldoncini, Alfonso; Bartolomei, Mirco; Boccaletto, Franco; Boero, Michele; Borsatti, Eugenio; Bruno, Andrea; Burroni, Luca; Capoccetti, Francesca; Castellani, Massimo; Cervino, Anna Rita; Chierichetti, Franca; Ciarmiello, Andrea; Corso, Angelo; Cuocolo, Alberto; De Rimini, Maria Luisa; Deandreis, Desiree’; Dottorini, Massimo Eugenio; Esposito, Filomena; Farsad, Mohsen; Gasparini, Massimo; [...]

Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

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  • Media type: E-Article
  • Title: Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study
  • Contributor: Albano, Domenico; Bertagna, Francesco; Alongi, Pierpaolo; Baldari, Sergio; Baldoncini, Alfonso; Bartolomei, Mirco; Boccaletto, Franco; Boero, Michele; Borsatti, Eugenio; Bruno, Andrea; Burroni, Luca; Capoccetti, Francesca; Castellani, Massimo; Cervino, Anna Rita; Chierichetti, Franca; Ciarmiello, Andrea; Corso, Angelo; Cuocolo, Alberto; De Rimini, Maria Luisa; Deandreis, Desiree’; Dottorini, Massimo Eugenio; Esposito, Filomena; Farsad, Mohsen; Gasparini, Massimo; [...]
  • imprint: Springer Science and Business Media LLC, 2021
  • Published in: European Journal of Nuclear Medicine and Molecular Imaging
  • Language: English
  • DOI: 10.1007/s00259-021-05219-0
  • ISSN: 1619-7070; 1619-7089
  • Keywords: Radiology, Nuclear Medicine and imaging ; General Medicine ; Radiology, Nuclear Medicine and imaging ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([<jats:sup>18</jats:sup>F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Overall, [<jats:sup>18</jats:sup>F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (<jats:italic>p</jats:italic> &lt; 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>A significant increase of interstitial pneumonia incidentally detected with [<jats:sup>18</jats:sup>F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.</jats:p> </jats:sec>