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Weidner, Kathrin; Behnes, Michael; Schupp, Tobias; Hoppner, Jorge; Ansari, Uzair; Mueller, Julian; Lindner, Simon; Borggrefe, Martin; Kim, Seung-hyun; Huseyinov, Aydin; Ellguth, Dominik; Akin, Muharrem; Meininghaus, Dirk Große; Bertsch, Thomas; Taton, Gabriel; Bollow, Armin; Reichelt, Thomas; Engelke, Niko; Reiser, Linda; Akin, Ibrahim

Chronic kidney disease impairs prognosis in electrical storm

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  • Media type: E-Article
  • Title: Chronic kidney disease impairs prognosis in electrical storm
  • Contributor: Weidner, Kathrin; Behnes, Michael; Schupp, Tobias; Hoppner, Jorge; Ansari, Uzair; Mueller, Julian; Lindner, Simon; Borggrefe, Martin; Kim, Seung-hyun; Huseyinov, Aydin; Ellguth, Dominik; Akin, Muharrem; Meininghaus, Dirk Große; Bertsch, Thomas; Taton, Gabriel; Bollow, Armin; Reichelt, Thomas; Engelke, Niko; Reiser, Linda; Akin, Ibrahim
  • imprint: Springer Science and Business Media LLC, 2022
  • Published in: Journal of Interventional Cardiac Electrophysiology
  • Language: English
  • DOI: 10.1007/s10840-020-00924-6
  • ISSN: 1383-875X; 1572-8595
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The study sought to assess the prognostic impact of chronic kidney disease (CKD) in patients with electrical storm (ES). ES represents a life-threatening heart rhythm disorder. In particular, CKD patients are at risk of suffering from ES. However, data regarding the prognostic impact of CKD on long-term mortality in ES patients is limited.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>All consecutive ES patients with an implantable cardioverter–defibrillator (ICD) were included retrospectively from 2002 to 2016. Patients with CKD (MDRD-GFR &lt; 60 ml/min/1.73 m<jats:sup>2</jats:sup>) were compared to patients without CKD. The primary endpoint was all-cause mortality at 3 years. Secondary endpoints were in-hospital mortality, cardiac rehospitalization, recurrences of electrical storm (ES-R), and major adverse cardiac events (MACE) at 3 years.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 70 consecutive ES patients were included. CKD was present in 43% of ES patients with a median glomerular filtration rate (GFR) of 43.3 ml/min/1.73 m<jats:sup>2</jats:sup>. CKD was associated with increased all-cause mortality at 3 years (63% vs. 20%; <jats:italic>p</jats:italic> = 0.001; HR = 4.293; 95% CI 1.874–9.836; <jats:italic>p</jats:italic> = 0.001) and MACE (57% vs. 30%; <jats:italic>p</jats:italic> = 0.025; HR = 3.597; 95% CI 1.679–7.708; <jats:italic>p</jats:italic> = 0.001). In contrast, first cardiac rehospitalization (43% vs. 45%; log-rank <jats:italic>p</jats:italic> = 0.889) and ES-R (30% vs. 20%; log-rank <jats:italic>p</jats:italic> = 0.334) were not affected by CKD. Even after multivariable adjustment, CKD was still associated with increased long-term mortality (HR = 2.397; 95% CI 1.012–5.697; <jats:italic>p</jats:italic> = 0.047), as well as with the secondary endpoint MACE (HR = 2.520; 95% CI 1.109–5.727; <jats:italic>p</jats:italic> = 0.027).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>In patients with ES, the presence of CKD was associated with increased long-term mortality and MACE.</jats:p> </jats:sec>