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Erro, Roberto; Pilotto, Andrea; Esposito, Marcello; Olivola, Enrica; Nicoletti, Alessandra; Lazzeri, Giulia; Magistrelli, Luca; Dallocchio, Carlo; Marchese, Roberta; Bologna, Matteo; Tessitore, Alessandro; Misceo, Salvatore; Gigante, Angelo Fabio; Terranova, Carmen; Moschella, Vincenzo; di Biase, Lazzaro; Di Giacopo, Raffaella; Morgante, Francesca; Valentino, Francesca; De Rosa, Anna; Trinchillo, Assunta; Malaguti, Maria Chiara; Brusa, Livia; Matinella, Angela; [...]

The Italian tremor Network (TITAN): rationale, design and preliminary findings

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  • Media type: E-Article
  • Title: The Italian tremor Network (TITAN): rationale, design and preliminary findings
  • Contributor: Erro, Roberto; Pilotto, Andrea; Esposito, Marcello; Olivola, Enrica; Nicoletti, Alessandra; Lazzeri, Giulia; Magistrelli, Luca; Dallocchio, Carlo; Marchese, Roberta; Bologna, Matteo; Tessitore, Alessandro; Misceo, Salvatore; Gigante, Angelo Fabio; Terranova, Carmen; Moschella, Vincenzo; di Biase, Lazzaro; Di Giacopo, Raffaella; Morgante, Francesca; Valentino, Francesca; De Rosa, Anna; Trinchillo, Assunta; Malaguti, Maria Chiara; Brusa, Livia; Matinella, Angela; [...]
  • imprint: Springer Science and Business Media LLC, 2022
  • Published in: Neurological Sciences
  • Language: English
  • DOI: 10.1007/s10072-022-06104-w
  • ISSN: 1590-3478; 1590-1874
  • Keywords: Psychiatry and Mental health ; Neurology (clinical) ; Dermatology ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Introduction</jats:title> <jats:p>The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such as ET-plus. As a result, precise information of demographics, clinical features, and about the natural history of these conditions are lacking. </jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>The ITAlian tremor Network (TITAN) is a multicenter data collection platform, the aim of which is to prospectively assess, according to a standardized protocol, the phenomenology and natural history of tremor syndromes.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>In the first year of activity, 679 patients have been recruited. The frequency of tremor syndromes varied from 32% of ET and 41% of ET-plus to less than 3% of rare forms, including focal tremors (2.30%), task-specific tremors (1.38%), isolated rest tremor (0.61%), and orthostatic tremor (0.61%). Patients with ET-plus were older and had a higher age at onset than ET, but a shorter disease duration, which might suggest that ET-plus is not a disease stage of ET. Familial aggregation of tremor and movement disorders was present in up to 60% of ET cases and in about 40% of patients with tremor combined with dystonia. The body site of tremor onset was different between tremor syndromes, with head tremor being most commonly, but not uniquely, associated with dystonia.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>The TITAN study is anticipated to provide clinically relevant prospective information about the clinical correlates of different tremor syndromes and their specific outcomes and might serve as a basis for future etiological, pathophysiological, and therapeutic research.</jats:p> </jats:sec>