Description:
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Purpose</jats:title>
<jats:p>Choroid plexus tumors comprise of choroid plexus papilloma (CPP, WHO grade I),
atypical choroid plexus papilloma (aCPP, WHO grade II) and choroid plexus carcinoma (CPC, WHO
grade III). Molecular events driving the majority of choroid plexus tumors remain poorly
understood. Recently, DNA methylation profiling has revealed different epigenetic
subgroups.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>Comprehensive review of epigenetic profiles of choroid plexus tumors in the
context of histopathological, genetic, and clinical features.</jats:p>
</jats:sec><jats:sec>
<jats:title>Summary</jats:title>
<jats:p>DNA methylation profiling segregates choroid plexus tumors into three distinct
epigenetic subgroups: supratentorial pediatric low-risk choroid plexus tumors (CPP and aCPP),
infratentorial adult low-risk choroid plexus tumors (CPP and aCPP), and supratentorial
pediatric high-risk choroid plexus tumors (CPP and aCPP and CPC). Epigenetic subgrouping
provides additional prognostic information in comparison to histopathological grading.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>Epigenetic profiling of choroid plexus tumors can be used for the
identification of patients at risk of recurrence and is expected to play a role for treatment
stratification and patient management in the context of future clinical trials.</jats:p>
</jats:sec>