Sachinidis, Agapios;
Locher, Rudolf;
Hoppe, Jürgen;
Vetter, Wilhelm
The platelet‐derived growth factor isomers, PDGF‐AA, PDGF‐AB and PDGF‐BB, induce contraction of vascular smooth muscle cells by different intracellular mechanisms
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Media type:
E-Article
Title:
The platelet‐derived growth factor isomers, PDGF‐AA, PDGF‐AB and PDGF‐BB, induce contraction of vascular smooth muscle cells by different intracellular mechanisms
Contributor:
Sachinidis, Agapios;
Locher, Rudolf;
Hoppe, Jürgen;
Vetter, Wilhelm
imprint:
Wiley, 1990
Published in:FEBS Letters
Language:
English
DOI:
10.1016/0014-5793(90)81447-v
ISSN:
0014-5793;
1873-3468
Origination:
Footnote:
Description:
<jats:p>The effect of human recombinant platelet‐derived growth factor (PDGF) isoforms, (r)PDGF‐AA, PDGF‐AB and PDGF‐BB, on contractility of rat aortic rings as well as on intercellular free Ca<jats:sup>2+</jats:sup> ([Ca<jats:sup>2+</jats:sup>]<jats:sub>i</jats:sub>), intracellular pH<jats:sub>i</jats:sub> (pH<jats:sub>i</jats:sub>) and thromboxane A<jats:sub>2</jats:sub> (TXA<jats:sub>2</jats:sub>) formation in cultured vascular smooth muscle cells (VSMC) was examined. PDGF‐BB behaved similar to PDGF‐AB and both have features characteristic of conventional vasocontrictor‐agonists that directly increase [Ca<jats:sup>2+</jats:sup>]<jats:sub>i</jats:sub>, activate the Na<jats:sup>+</jats:sup>/H<jats:sup>+</jats:sup> exchanger, stimulate the TXA<jats:sub>2</jats:sub> formation, and induced contraction in VSMC whereas PDGF‐AA induced contraction without increasing of [Ca<jats:sup>2+</jats:sup>]<jats:sub>i</jats:sub>, pH<jats:sub>i</jats:sub>, and TXA<jats:sub>2</jats:sub> formation.</jats:p>