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Media type:
E-Article
Title:
Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2
Contributor:
Ostareck‐Lederer, Antje;
Ostareck, Dirk H.
Published:
Wiley, 2004
Published in:
Biology of the Cell, 96 (2004) 6, Seite 407-411
Language:
English
DOI:
10.1016/j.biolcel.2004.03.010
ISSN:
0248-4900;
1768-322X
Origination:
Footnote:
Description:
Summry— Studies on the post‐transcriptional regulation of gene expression in haematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. HnRNP K and hnRNP E1/E2 share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KH‐domains are components of a modular system, which enables these proteins to engage in both, protein/nucleic acid and protein/protein interactions, the latter generating connectivity to cell signalling events. As components of different mRNA‐protein complexes, hnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability in haematopoietic cell differentiation.