Description:
AbstractCardiac contractility modulating (CCM) signals delivered by the OPTIMIZER System are being investigated as a treatment for medically refractory heart failure. Previous chronic studies of CCM have excluded patients with prolonged QRS and a cardiac resynchronization therapy (CRT) device. However, symptoms persist in more than 25% of these CRT patients. CCM may offer a therapeutic option for these non‐responders. Here we report the first use of CCM signals in a patient who did not respond to treatment with a CRT‐D device. We show that the implantation is technically feasible, that the OPTIMIZER and CRT‐D devices can coexist without interference and that acute haemodynamic and clinical improvements can be observed. The results suggest that systematic investigation of CCM treatment in CRT non‐responders is warranted.