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Riou, Denis; Roussakis, Christos; Robillard, Nelly; Biard, Jean‐François; Verbist, Jean‐François

Bistramide A‐induced irreversible arrest of cell proliferation in a non‐small‐cell bronchopulmonary carcinoma is similar to induction of terminal maturation

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  • Media type: E-Article
  • Title: Bistramide A‐induced irreversible arrest of cell proliferation in a non‐small‐cell bronchopulmonary carcinoma is similar to induction of terminal maturation
  • Contributor: Riou, Denis; Roussakis, Christos; Robillard, Nelly; Biard, Jean‐François; Verbist, Jean‐François
  • Published: Wiley, 1993
  • Published in: Biology of the Cell, 77 (1993) 3, Seite 261-264
  • Language: English
  • DOI: 10.1016/s0248-4900(05)80196-0
  • ISSN: 1768-322X; 0248-4900
  • Keywords: Cell Biology ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p><jats:bold>Summary—</jats:bold> Bistramide A, a new toxin isolated from a New Caledonian Urochordata, shows an antiproliferative effect on a non‐small‐cell lung carcinoma line <jats:italic>in vitro</jats:italic> and G1‐blockade. In this work, the growth arrest induced by bistramide A was shown to be irreversible as assessed by growth kinetics of pretreated cells. Furthermore, the drug caused an underexpression of the nuclear antigen Ki67. These events are similar to a G1‐differentiation cell cycle step blockage and a terminal maturation induction.</jats:p>