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Media type:
E-Article
Title:
Rate of segregation due to plasmid incompatibility
Contributor:
Cullum, John;
Broda, Paul
Published:
Hindawi Limited, 1979
Published in:
Genetical Research, 33 (1979) 1, Seite 61-79
Language:
English
DOI:
10.1017/s0016672300018176
ISSN:
0016-6723;
1469-5073
Origination:
Footnote:
Description:
SUMMARYWe calculated the rates of segregation due to plasmid incompatibility under several simple models. A common feature of all the models that we considered is that incompatibility is caused by the inability of the segregation mechanism to distinguish between two incompatible plasmids.We measured the rate of segregation due to incompatibility of a pair of ColE1 derivatives under two conditions: (1) One plasmid was introduced into cells carrying the other by conjugation. (2) Cells carrying both plasmids were maintained by selection and then selection was released.Interpretation of the results was made more difficult by effects of the Plasmids on the host cell's growth rate. These experiments gave results in agreement with the predictions of a random pool replication model. Published results were also in reasonable agreement with this model.