Grangeon, Maria Conceição;
Seixas, Camila;
Quarantini, Lucas C.;
Miranda-Scippa, Angela;
Pompili, Maurizio;
Steffens, David C.;
Wenzel, Amy;
Lacerda, Acioly L. T.;
de Oliveira, Irismar Reis
White Matter Hyperintensities and Their Association With Suicidally in Major Affective Disorders: A Meta-Analysis of Magnetic Resonance Imaging Studies
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Media type:
E-Article
Title:
White Matter Hyperintensities and Their Association With Suicidally in Major Affective Disorders: A Meta-Analysis of Magnetic Resonance Imaging Studies
Contributor:
Grangeon, Maria Conceição;
Seixas, Camila;
Quarantini, Lucas C.;
Miranda-Scippa, Angela;
Pompili, Maurizio;
Steffens, David C.;
Wenzel, Amy;
Lacerda, Acioly L. T.;
de Oliveira, Irismar Reis
Description:
<jats:title>ABSTRACT</jats:title>
<jats:p><jats:bold>Introduction:</jats:bold> Individuals who have deep and
periventricular white matter hyperintensities may have a higher risk for
suicidal behavior. There are mixed results in the literature regarding
whether unipolar or bipolar patients who have attempted suicide have more
deep white matter hyperintensities (DWMH) or periventricular
hyperintensities (PVH) relative to those who have no history of suicide
attempts.</jats:p>
<jats:p><jats:bold>Methods:</jats:bold> A meta-analysis of studies examining
white matter hyperintensities (WMH) in mood disorder patients with and
without a history of suicide attempts was performed.</jats:p>
<jats:p><jats:bold>Results:</jats:bold> Four studies, including a total of 173
patients who attempted suicide and 183 who did not attempt suicide, were
included. A significantly higher number of attempters were found to have WMH
than non-attempters. Unipolar depressed patients who had attempted suicide
had 1.9 times more DWMH and 2.1 times more PVH than those who did not.
Bipolar patients who had attempted suicide had 5.4 times more PVH than those
who had not. Taken together, unipolar and bipolar patients who had attempted
suicide had 2.8 times more DWMH and 4.5 times more PVH than those who had
never attempted suicide.</jats:p>