• Media type: E-Article
  • Title: Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722)
  • Contributor: Woodward, Hannah L.; Innocenti, Paolo; Cheung, Kwai-Ming J.; Hayes, Angela; Roberts, Jennie; Henley, Alan T.; Faisal, Amir; Mak, Grace Wing-Yan; Box, Gary; Westwood, Isaac M.; Cronin, Nora; Carter, Michael; Valenti, Melanie; De Haven Brandon, Alexis; O’Fee, Lisa; Saville, Harry; Schmitt, Jessica; Burke, Rosemary; Broccatelli, Fabio; van Montfort, Rob L. M.; Raynaud, Florence I.; Eccles, Suzanne A.; Linardopoulos, Spiros; Blagg, Julian;
  • Published: American Chemical Society (ACS), 2018
  • Published in: Journal of Medicinal Chemistry, 61 (2018) 18, Seite 8226-8240
  • Language: English
  • DOI: 10.1021/acs.jmedchem.8b00690
  • ISSN: 0022-2623; 1520-4804
  • Origination:
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