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Vijai, Joseph; Wang, Zhaoming; Berndt, Sonja I.; Skibola, Christine F.; Slager, Susan L.; de Sanjose, Silvia; Melbye, Mads; Glimelius, Bengt; Bracci, Paige M.; Conde, Lucia; Birmann, Brenda M.; Wang, Sophia S.; Brooks-Wilson, Angela R.; Lan, Qing; de Bakker, Paul I. W.; Vermeulen, Roel C. H.; Portlock, Carol; Ansell, Stephen M.; Link, Brian K.; Riby, Jacques; North, Kari E.; Gu, Jian; Hjalgrim, Henrik; Cozen, Wendy; [...]

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

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  • Media type: E-Article
  • Title: A genome-wide association study of marginal zone lymphoma shows association to the HLA region
  • Contributor: Vijai, Joseph; Wang, Zhaoming; Berndt, Sonja I.; Skibola, Christine F.; Slager, Susan L.; de Sanjose, Silvia; Melbye, Mads; Glimelius, Bengt; Bracci, Paige M.; Conde, Lucia; Birmann, Brenda M.; Wang, Sophia S.; Brooks-Wilson, Angela R.; Lan, Qing; de Bakker, Paul I. W.; Vermeulen, Roel C. H.; Portlock, Carol; Ansell, Stephen M.; Link, Brian K.; Riby, Jacques; North, Kari E.; Gu, Jian; Hjalgrim, Henrik; Cozen, Wendy; [...]
  • imprint: Springer Science and Business Media LLC, 2015
  • Published in: Nature Communications
  • Language: English
  • DOI: 10.1038/ncomms6751
  • ISSN: 2041-1723
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near <jats:italic>BTNL2</jats:italic> (rs9461741, <jats:italic>P</jats:italic>=3.95 × 10<jats:sup>−15</jats:sup>) and <jats:italic>HLA-B</jats:italic> (rs2922994, <jats:italic>P</jats:italic>=2.43 × 10<jats:sup>−9</jats:sup>) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.</jats:p>
  • Access State: Open Access