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Lu, Yingchang; Day, Felix R.; Gustafsson, Stefan; Buchkovich, Martin L.; Na, Jianbo; Bataille, Veronique; Cousminer, Diana L.; Dastani, Zari; Drong, Alexander W.; Esko, Tõnu; Evans, David M.; Falchi, Mario; Feitosa, Mary F.; Ferreira, Teresa; Hedman, Åsa K.; Haring, Robin; Hysi, Pirro G.; Iles, Mark M.; Justice, Anne E.; Kanoni, Stavroula; Lagou, Vasiliki; Li, Rui; Li, Xin; Locke, Adam; [...]

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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  • Media type: E-Article
  • Title: New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
  • Contributor: Lu, Yingchang; Day, Felix R.; Gustafsson, Stefan; Buchkovich, Martin L.; Na, Jianbo; Bataille, Veronique; Cousminer, Diana L.; Dastani, Zari; Drong, Alexander W.; Esko, Tõnu; Evans, David M.; Falchi, Mario; Feitosa, Mary F.; Ferreira, Teresa; Hedman, Åsa K.; Haring, Robin; Hysi, Pirro G.; Iles, Mark M.; Justice, Anne E.; Kanoni, Stavroula; Lagou, Vasiliki; Li, Rui; Li, Xin; Locke, Adam; [...]
  • imprint: Springer Science and Business Media LLC, 2016
  • Published in: Nature Communications
  • Language: English
  • DOI: 10.1038/ncomms10495
  • ISSN: 2041-1723
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (<jats:italic>P</jats:italic>&lt;5 × 10<jats:sup>−8</jats:sup>), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near <jats:italic>COBLL1/GRB14</jats:italic>, <jats:italic>IGF2BP1</jats:italic>, <jats:italic>PLA2G6</jats:italic>, <jats:italic>CRTC1</jats:italic>) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.</jats:p>
  • Access State: Open Access