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Media type:
E-Article
Title:
Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus
Contributor:
Aqrabawi, Afif J.;
Browne, Caleb J.;
Dargaei, Zahra;
Garand, Danielle;
Khademullah, C. Sahara;
Woodin, Melanie A.;
Kim, Jun Chul
Published:
Springer Science and Business Media LLC, 2016
Published in:
Nature Communications, 7 (2016) 1
Language:
English
DOI:
10.1038/ncomms13721
ISSN:
2041-1723
Origination:
Footnote:
Description:
AbstractOlfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis (mAON) bidirectionally modulates olfactory sensitivity and olfaction-dependent behaviours. To identify a limbic input that tunes this mAON switch, we further demonstrate that optogenetic stimulation of ventral hippocampal inputs to the mAON is sufficient to alter olfaction-dependent behaviours.