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Media type:
E-Article
Title:
Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation
Contributor:
Sladky, Valentina C.;
Villunger, Andreas
Published:
Springer Science and Business Media LLC, 2020
Published in:
Cell Death & Differentiation, 27 (2020) 7, Seite 2037-2047
Language:
English
DOI:
10.1038/s41418-020-0556-6
ISSN:
1350-9047;
1476-5403
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:p>The PIDDosome is a multiprotein complex that drives activation of caspase-2, an endopeptidase originally implicated in apoptosis. Yet, unlike other caspases involved in cell death and inflammation, caspase-2 seems to exert additional versatile functions unrelated to cell death. These emerging roles range from control of transcription factor activity to ploidy surveillance. Thus, caspase-2 and the PIDDosome act as a critical regulatory unit controlling cellular differentiation processes during organogenesis and regeneration. These newly established functions of the PIDDosome and its downstream effector render its components attractive targets for drug-development aiming to prevent fatty liver diseases, neurodegenerative disorders or osteoporosis.</jats:p>