> Details

Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid M.; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim R.; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.

CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection
  • Contributor: Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid M.; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim R.; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.
  • imprint: Springer Science and Business Media LLC, 2018
  • Published in: Nature Communications
  • Language: English
  • DOI: 10.1038/s41467-018-04832-2
  • ISSN: 2041-1723
  • Keywords: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Dysfunction of CD8<jats:sup>+</jats:sup> T cells can lead to the development of chronic viral infection. Identifying mechanisms responsible for such T cell dysfunction is therefore of great importance to understand how to prevent persistent viral infection. Here we show using lymphocytic choriomeningitis virus (LCMV) infection that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is fundamental for recruiting lymphocyte-specific protein kinase (Lck) into the T cell receptor complex to form an efficient immunological synapse. CEACAM1 is essential for activation of CD8<jats:sup>+</jats:sup> T cells, and the absence of CEACAM1 on virus-specific CD8<jats:sup>+</jats:sup> T cells limits the antiviral CD8<jats:sup>+</jats:sup> T cell response. Treatment with anti-CEACAM1 antibody stabilizes Lck in the immunological synapse, prevents CD8<jats:sup>+</jats:sup> T cell exhaustion, and improves control of virus infection in vivo. Treatment of human virus-specific CD8<jats:sup>+</jats:sup> T cells with anti-CEACAM1 antibody similarly enhances their proliferation. We conclude that CEACAM1 is an important regulator of virus-specific CD8<jats:sup>+</jats:sup> T cell functions in mice and humans and represents a promising therapeutic target for modulating CD8<jats:sup>+</jats:sup> T cells.</jats:p>
  • Access State: Open Access