> Details

Park, Se Eun; Pham, Duy Thanh; Boinett, Christine; Wong, Vanessa K.; Pak, Gi Deok; Panzner, Ursula; Espinoza, Ligia Maria Cruz; von Kalckreuth, Vera; Im, Justin; Schütt-Gerowitt, Heidi; Crump, John A.; Breiman, Robert F.; Adu-Sarkodie, Yaw; Owusu-Dabo, Ellis; Rakotozandrindrainy, Raphaël; Soura, Abdramane Bassiahi; Aseffa, Abraham; Gasmelseed, Nagla; Keddy, Karen H.; May, Jürgen; Sow, Amy Gassama; Aaby, Peter; Biggs, Holly M.; Hertz, Julian T.; [...]

The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa

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  • Media type: E-Article
  • Title: The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa
  • Contributor: Park, Se Eun; Pham, Duy Thanh; Boinett, Christine; Wong, Vanessa K.; Pak, Gi Deok; Panzner, Ursula; Espinoza, Ligia Maria Cruz; von Kalckreuth, Vera; Im, Justin; Schütt-Gerowitt, Heidi; Crump, John A.; Breiman, Robert F.; Adu-Sarkodie, Yaw; Owusu-Dabo, Ellis; Rakotozandrindrainy, Raphaël; Soura, Abdramane Bassiahi; Aseffa, Abraham; Gasmelseed, Nagla; Keddy, Karen H.; May, Jürgen; Sow, Amy Gassama; Aaby, Peter; Biggs, Holly M.; Hertz, Julian T.; [...]
  • imprint: Springer Science and Business Media LLC, 2018
  • Published in: Nature Communications
  • Language: English
  • DOI: 10.1038/s41467-018-07370-z
  • ISSN: 2041-1723
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) <jats:italic>Salmonella</jats:italic> Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous <jats:italic>S</jats:italic>. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global <jats:italic>S</jats:italic>. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR <jats:italic>S</jats:italic>. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged &lt;15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa.</jats:p>
  • Access State: Open Access