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Spyrou, Maria A.; Keller, Marcel; Tukhbatova, Rezeda I.; Scheib, Christiana L.; Nelson, Elizabeth A.; Andrades Valtueña, Aida; Neumann, Gunnar U.; Walker, Don; Alterauge, Amelie; Carty, Niamh; Cessford, Craig; Fetz, Hermann; Gourvennec, Michaël; Hartle, Robert; Henderson, Michael; von Heyking, Kristin; Inskip, Sarah A.; Kacki, Sacha; Key, Felix M.; Knox, Elizabeth L.; Later, Christian; Maheshwari-Aplin, Prishita; Peters, Joris; Robb, John E.; [...]

Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes

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  • Media type: E-Article
  • Title: Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes
  • Contributor: Spyrou, Maria A.; Keller, Marcel; Tukhbatova, Rezeda I.; Scheib, Christiana L.; Nelson, Elizabeth A.; Andrades Valtueña, Aida; Neumann, Gunnar U.; Walker, Don; Alterauge, Amelie; Carty, Niamh; Cessford, Craig; Fetz, Hermann; Gourvennec, Michaël; Hartle, Robert; Henderson, Michael; von Heyking, Kristin; Inskip, Sarah A.; Kacki, Sacha; Key, Felix M.; Knox, Elizabeth L.; Later, Christian; Maheshwari-Aplin, Prishita; Peters, Joris; Robb, John E.; [...]
  • imprint: Springer Science and Business Media LLC, 2019
  • Published in: Nature Communications
  • Language: English
  • DOI: 10.1038/s41467-019-12154-0
  • ISSN: 2041-1723
  • Keywords: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>The second plague pandemic, caused by <jats:italic>Yersinia pestis</jats:italic>, devastated Europe and the nearby regions between the 14<jats:sup>th</jats:sup> and 18<jats:sup>th</jats:sup> centuries AD. Here we analyse human remains from ten European archaeological sites spanning this period and reconstruct 34 ancient <jats:italic>Y. pestis</jats:italic> genomes. Our data support an initial entry of the bacterium through eastern Europe, the absence of genetic diversity during the Black Death, and low within-outbreak diversity thereafter. Analysis of post-Black Death genomes shows the diversification of a <jats:italic>Y. pestis</jats:italic> lineage into multiple genetically distinct clades that may have given rise to more than one disease reservoir in, or close to, Europe. In addition, we show the loss of a genomic region that includes virulence-related genes in strains associated with late stages of the pandemic. The deletion was also identified in genomes connected with the first plague pandemic (541–750 AD), suggesting a comparable evolutionary trajectory of <jats:italic>Y. pestis</jats:italic> during both events.</jats:p>
  • Access State: Open Access