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Gonzalez-Ortiz, Fernando; Kirsebom, Bjørn-Eivind; Contador, José; Tanley, Jordan E.; Selnes, Per; Gísladóttir, Berglind; Pålhaugen, Lene; Suhr Hemminghyth, Mathilde; Jarholm, Jonas; Skogseth, Ragnhild; Bråthen, Geir; Grøndtvedt, Gøril; Bjørnerud, Atle; Tecelao, Sandra; Waterloo, Knut; Aarsland, Dag; Fernández-Lebrero, Aida; García-Escobar, Greta; Navalpotro-Gómez, Irene; Turton, Michael; Hesthamar, Agnes; Kac, Przemyslaw R.; Nilsson, Johanna; Luchsinger, Jose; [...]

Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease

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  • Media type: E-Article
  • Title: Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease
  • Contributor: Gonzalez-Ortiz, Fernando; Kirsebom, Bjørn-Eivind; Contador, José; Tanley, Jordan E.; Selnes, Per; Gísladóttir, Berglind; Pålhaugen, Lene; Suhr Hemminghyth, Mathilde; Jarholm, Jonas; Skogseth, Ragnhild; Bråthen, Geir; Grøndtvedt, Gøril; Bjørnerud, Atle; Tecelao, Sandra; Waterloo, Knut; Aarsland, Dag; Fernández-Lebrero, Aida; García-Escobar, Greta; Navalpotro-Gómez, Irene; Turton, Michael; Hesthamar, Agnes; Kac, Przemyslaw R.; Nilsson, Johanna; Luchsinger, Jose; [...]
  • imprint: Springer Science and Business Media LLC, 2024
  • Published in: Nature Communications
  • Language: English
  • DOI: 10.1038/s41467-024-47286-5
  • ISSN: 2041-1723
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer’s disease (AD). In blood, phosphorylated tau (p-tau) associates with Aβ pathophysiology but an AD-type neurodegeneration biomarker has been lacking. In this multicenter study (<jats:italic>n</jats:italic> = 1076), we show that brain-derived tau (BD-tau) in blood increases according to concomitant Aβ (“A”) and neurodegeneration (“N”) abnormalities (determined using cerebrospinal fluid biomarkers); We used blood-based A/N biomarkers to profile the participants in this study; individuals with blood-based p-tau+/BD-tau+ profiles had the fastest cognitive decline and atrophy rates, irrespective of the baseline cognitive status. Furthermore, BD-tau showed no or much weaker correlations with age, renal function, other comorbidities/risk factors and self-identified race/ethnicity, compared with other blood biomarkers. Here we show that blood-based BD-tau is a biomarker for identifying Aβ-positive individuals at risk of short-term cognitive decline and atrophy, with implications for clinical trials and implementation of anti-Aβ therapies.</jats:p>
  • Access State: Open Access