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Ebinger, Arnt; Santos, Pauline D.; Pfaff, Florian; Dürrwald, Ralf; Kolodziejek, Jolanta; Schlottau, Kore; Ruf, Viktoria; Liesche-Starnecker, Friederike; Ensser, Armin; Korn, Klaus; Ulrich, Reiner; Fürstenau, Jenny; Matiasek, Kaspar; Hansmann, Florian; Seuberlich, Torsten; Nobach, Daniel; Müller, Matthias; Neubauer-Juric, Antonie; Suchowski, Marcel; Bauswein, Markus; Niller, Hans-Helmut; Schmidt, Barbara; Tappe, Dennis; Cadar, Daniel; [...]

Lethal Borna disease virus 1 infections of humans and animals – in-depth molecular epidemiology and phylogeography

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  • Media type: E-Article
  • Title: Lethal Borna disease virus 1 infections of humans and animals – in-depth molecular epidemiology and phylogeography
  • Contributor: Ebinger, Arnt; Santos, Pauline D.; Pfaff, Florian; Dürrwald, Ralf; Kolodziejek, Jolanta; Schlottau, Kore; Ruf, Viktoria; Liesche-Starnecker, Friederike; Ensser, Armin; Korn, Klaus; Ulrich, Reiner; Fürstenau, Jenny; Matiasek, Kaspar; Hansmann, Florian; Seuberlich, Torsten; Nobach, Daniel; Müller, Matthias; Neubauer-Juric, Antonie; Suchowski, Marcel; Bauswein, Markus; Niller, Hans-Helmut; Schmidt, Barbara; Tappe, Dennis; Cadar, Daniel; [...]
  • Published: Springer Science and Business Media LLC, 2024
  • Published in: Nature Communications, 15 (2024) 1
  • Language: English
  • DOI: 10.1038/s41467-024-52192-x
  • ISSN: 2041-1723
  • Origination:
  • Footnote:
  • Description: AbstractBorna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored white-toothed shrew (Crocidura leucodon). The known BoDV-1-endemic area is remarkably restricted to parts of Germany, Austria, Switzerland and Liechtenstein. To gain comprehensive data on its occurrence, we analysed diagnostic material from suspected BoDV-1-induced encephalitis cases based on clinical and/or histopathological diagnosis. BoDV-1 infection was confirmed by RT-qPCR in 207 domestic mammals, 28 humans and seven wild shrews. Thereby, this study markedly raises the number of published laboratory-confirmed human BoDV-1 infections and provides a first comprehensive summary. Generation of 136 new BoDV-1 genome sequences from animals and humans facilitated an in-depth phylogeographic analysis, allowing for the definition of risk areas for zoonotic BoDV-1 transmission and facilitating the assessment of geographical infection sources. Consistent with the low mobility of its reservoir host, BoDV-1 sequences showed a remarkable geographic association, with individual phylogenetic clades occupying distinct areas. The closest genetic relatives of most human-derived BoDV-1 sequences were located at distances of less than 40 km, indicating that spill-over transmission from the natural reservoir usually occurs in the patient´s home region.
  • Access State: Open Access