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Ng, Ashley P.; Coughlan, Hannah D.; Hediyeh-zadeh, Soroor; Behrens, Kira; Johanson, Timothy M.; Low, Michael Sze Yuan; Bell, Charles C.; Gilan, Omer; Chan, Yih-Chih; Kueh, Andrew J.; Boudier, Thomas; Feltham, Rebecca; Gabrielyan, Anna; DiRago, Ladina; Hyland, Craig D.; Ierino, Helen; Mifsud, Sandra; Viney, Elizabeth; Willson, Tracy; Dawson, Mark A.; Allan, Rhys S.; Herold, Marco J.; Rogers, Kelly; Tarlinton, David M.; [...]

An Erg-driven transcriptional program controls B cell lymphopoiesis

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  • Media type: E-Article
  • Title: An Erg-driven transcriptional program controls B cell lymphopoiesis
  • Contributor: Ng, Ashley P.; Coughlan, Hannah D.; Hediyeh-zadeh, Soroor; Behrens, Kira; Johanson, Timothy M.; Low, Michael Sze Yuan; Bell, Charles C.; Gilan, Omer; Chan, Yih-Chih; Kueh, Andrew J.; Boudier, Thomas; Feltham, Rebecca; Gabrielyan, Anna; DiRago, Ladina; Hyland, Craig D.; Ierino, Helen; Mifsud, Sandra; Viney, Elizabeth; Willson, Tracy; Dawson, Mark A.; Allan, Rhys S.; Herold, Marco J.; Rogers, Kelly; Tarlinton, David M.; [...]
  • imprint: Springer Science and Business Media LLC, 2020
  • Published in: Nature Communications
  • Language: English
  • DOI: 10.1038/s41467-020-16828-y
  • ISSN: 2041-1723
  • Keywords: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimately generating mature B cells. This highly regulated process generates clonal immunological diversity via recombination of immunoglobulin V, D and J gene segments. While several transcription factors that control B cell development and V(D)J recombination have been defined, how these processes are initiated and coordinated into a precise regulatory network remains poorly understood. Here, we show that the transcription factor ETS Related Gene (<jats:italic>Erg</jats:italic>) is essential for early B lymphoid differentiation. Erg initiates a transcriptional network involving the B cell lineage defining genes, <jats:italic>Ebf1</jats:italic> and <jats:italic>Pax5</jats:italic>, which directly promotes expression of key genes involved in V(D)J recombination and formation of the B cell receptor. Complementation of Erg deficiency with a productively rearranged immunoglobulin gene rescued B lineage development, demonstrating that Erg is an essential and stage-specific regulator of the gene regulatory network controlling B lymphopoiesis.</jats:p>
  • Access State: Open Access