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Weinberger, Tobias; Esfandyari, Dena; Messerer, Denise; Percin, Gulce; Schleifer, Christian; Thaler, Raffael; Liu, Lulu; Stremmel, Christopher; Schneider, Vanessa; Vagnozzi, Ronald J.; Schwanenkamp, Jennifer; Fischer, Maximilian; Busch, Katrin; Klapproth, Kay; Ishikawa-Ankerhold, Hellen; Klösges, Lukas; Titova, Anna; Molkentin, Jeffery D.; Kobayashi, Yasuhiro; Engelhardt, Stefan; Massberg, Steffen; Waskow, Claudia; Perdiguero, Elisa Gomez; Schulz, Christian

Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation

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  • Media type: E-Article
  • Title: Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation
  • Contributor: Weinberger, Tobias; Esfandyari, Dena; Messerer, Denise; Percin, Gulce; Schleifer, Christian; Thaler, Raffael; Liu, Lulu; Stremmel, Christopher; Schneider, Vanessa; Vagnozzi, Ronald J.; Schwanenkamp, Jennifer; Fischer, Maximilian; Busch, Katrin; Klapproth, Kay; Ishikawa-Ankerhold, Hellen; Klösges, Lukas; Titova, Anna; Molkentin, Jeffery D.; Kobayashi, Yasuhiro; Engelhardt, Stefan; Massberg, Steffen; Waskow, Claudia; Perdiguero, Elisa Gomez; Schulz, Christian
  • imprint: Springer Science and Business Media LLC, 2020
  • Published in: Nature Communications
  • Language: English
  • DOI: 10.1038/s41467-020-18287-x
  • ISSN: 2041-1723
  • Keywords: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Arterial macrophages have different developmental origins, but the association of macrophage ontogeny with their phenotypes and functions in adulthood is still unclear. Here, we combine macrophage fate-mapping analysis with single-cell RNA sequencing to establish their cellular identity during homeostasis, and in response to angiotensin-II (AngII)-induced arterial inflammation. Yolk sac erythro-myeloid progenitors (EMP) contribute substantially to adventitial macrophages and give rise to a defined cluster of resident immune cells with homeostatic functions that is stable in adult mice, but declines in numbers during ageing and is not replenished by bone marrow (BM)-derived macrophages. In response to AngII inflammation, increase in adventitial macrophages is driven by recruitment of BM monocytes, while EMP-derived macrophages proliferate locally and provide a distinct transcriptional response that is linked to tissue regeneration. Our findings thus contribute to the understanding of macrophage heterogeneity, and associate macrophage ontogeny with distinct functions in health and disease.</jats:p>
  • Access State: Open Access