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Aggarwal, Dinesh; Warne, Ben; Jahun, Aminu S.; Hamilton, William L.; Fieldman, Thomas; du Plessis, Louis; Hill, Verity; Blane, Beth; Watkins, Emmeline; Wright, Elizabeth; Hall, Grant; Ludden, Catherine; Myers, Richard; Hosmillo, Myra; Chaudhry, Yasmin; Pinckert, Malte L.; Georgana, Iliana; Izuagbe, Rhys; Leek, Danielle; Nsonwu, Olisaeloka; Hughes, Gareth J.; Packer, Simon; Page, Andrew J.; Metaxaki, Marina; [...]

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

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  • Media type: E-Article
  • Title: Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
  • Contributor: Aggarwal, Dinesh; Warne, Ben; Jahun, Aminu S.; Hamilton, William L.; Fieldman, Thomas; du Plessis, Louis; Hill, Verity; Blane, Beth; Watkins, Emmeline; Wright, Elizabeth; Hall, Grant; Ludden, Catherine; Myers, Richard; Hosmillo, Myra; Chaudhry, Yasmin; Pinckert, Malte L.; Georgana, Iliana; Izuagbe, Rhys; Leek, Danielle; Nsonwu, Olisaeloka; Hughes, Gareth J.; Packer, Simon; Page, Andrew J.; Metaxaki, Marina; [...]
  • imprint: Springer Science and Business Media LLC, 2022
  • Published in: Nature Communications
  • Language: English
  • DOI: 10.1038/s41467-021-27942-w
  • ISSN: 2041-1723
  • Keywords: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Understanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.</jats:p>
  • Access State: Open Access