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Steenblock, Charlotte; Richter, Stefanie; Berger, Ilona; Barovic, Marko; Schmid, Janine; Schubert, Undine; Jarzebska, Natalia; von Mässenhausen, Anne; Linkermann, Andreas; Schürmann, Annette; Pablik, Jessica; Dienemann, Thomas; Evert, Katja; Rodionov, Roman N.; Semenova, Natalia Y.; Zinserling, Vsevolod A.; Gainetdinov, Raul R.; Baretton, Gustavo; Lindemann, Dirk; Solimena, Michele; Ludwig, Barbara; Bornstein, Stefan R.

Viral infiltration of pancreatic islets in patients with COVID-19

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  • Media type: E-Article
  • Title: Viral infiltration of pancreatic islets in patients with COVID-19
  • Contributor: Steenblock, Charlotte; Richter, Stefanie; Berger, Ilona; Barovic, Marko; Schmid, Janine; Schubert, Undine; Jarzebska, Natalia; von Mässenhausen, Anne; Linkermann, Andreas; Schürmann, Annette; Pablik, Jessica; Dienemann, Thomas; Evert, Katja; Rodionov, Roman N.; Semenova, Natalia Y.; Zinserling, Vsevolod A.; Gainetdinov, Raul R.; Baretton, Gustavo; Lindemann, Dirk; Solimena, Michele; Ludwig, Barbara; Bornstein, Stefan R.
  • Published: Springer Science and Business Media LLC, 2021
  • Published in: Nature Communications, 12 (2021) 1
  • Language: English
  • DOI: 10.1038/s41467-021-23886-3
  • ISSN: 2041-1723
  • Origination:
  • Footnote:
  • Description: AbstractMetabolic diseases are associated with an increased risk of severe COVID-19 and conversely, new-onset hyperglycemia and complications of preexisting diabetes have been observed in COVID-19 patients. Here, we performed a comprehensive analysis of pancreatic autopsy tissue from COVID-19 patients using immunofluorescence, immunohistochemistry, RNA scope and electron microscopy and detected SARS-CoV-2 viral infiltration of beta-cells in all patients. Using SARS-CoV-2 pseudoviruses, we confirmed that isolated human islet cells are permissive to infection. In eleven COVID-19 patients, we examined the expression of ACE2, TMPRSS and other receptors and factors, such as DPP4, HMBG1 and NRP1, that might facilitate virus entry. Whereas 70% of the COVID-19 patients expressed ACE2 in the vasculature, only 30% displayed ACE2-expression in beta-cells. Even in the absence of manifest new-onset diabetes, necroptotic cell death, immune cell infiltration and SARS-CoV-2 viral infection of pancreatic beta-cells may contribute to varying degrees of metabolic dysregulation in patients with COVID-19.
  • Access State: Open Access