> Details

Ito, Jumpei; Suzuki, Rigel; Uriu, Keiya; Itakura, Yukari; Zahradnik, Jiri; Kimura, Kanako Terakado; Deguchi, Sayaka; Wang, Lei; Lytras, Spyros; Tamura, Tomokazu; Kida, Izumi; Nasser, Hesham; Shofa, Maya; Begum, Mst Monira; Tsuda, Masumi; Oda, Yoshitaka; Suzuki, Tateki; Sasaki, Jiei; Sasaki-Tabata, Kaori; Fujita, Shigeru; Yoshimatsu, Kumiko; Ito, Hayato; Nao, Naganori; Asakura, Hiroyuki; [...]

Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant
  • Contributor: Ito, Jumpei; Suzuki, Rigel; Uriu, Keiya; Itakura, Yukari; Zahradnik, Jiri; Kimura, Kanako Terakado; Deguchi, Sayaka; Wang, Lei; Lytras, Spyros; Tamura, Tomokazu; Kida, Izumi; Nasser, Hesham; Shofa, Maya; Begum, Mst Monira; Tsuda, Masumi; Oda, Yoshitaka; Suzuki, Tateki; Sasaki, Jiei; Sasaki-Tabata, Kaori; Fujita, Shigeru; Yoshimatsu, Kumiko; Ito, Hayato; Nao, Naganori; Asakura, Hiroyuki; [...]
  • imprint: Springer Science and Business Media LLC, 2023
  • Published in: Nature Communications
  • Language: English
  • DOI: 10.1038/s41467-023-38188-z
  • ISSN: 2041-1723
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These variants convergently acquired amino acid substitutions at critical residues in the spike protein, including residues R346, K444, L452, N460, and F486. Here, we characterize the convergent evolution of Omicron subvariants and the properties of one recent lineage of concern, BQ.1.1. Our phylogenetic analysis suggests that these five substitutions are recurrently acquired, particularly in younger Omicron lineages. Epidemic dynamics modelling suggests that the five substitutions increase viral fitness, and a large proportion of the fitness variation within Omicron lineages can be explained by these substitutions. Compared to BA.5, BQ.1.1 evades breakthrough BA.2 and BA.5 infection sera more efficiently, as demonstrated by neutralization assays. The pathogenicity of BQ.1.1 in hamsters is lower than that of BA.5. Our multiscale investigations illuminate the evolutionary rules governing the convergent evolution for known Omicron lineages as of 2022.</jats:p>
  • Access State: Open Access