> Details

Muranen, Taru A.; Khan, Sofia; Fagerholm, Rainer; Aittomäki, Kristiina; Cunningham, Julie M.; Dennis, Joe; Leslie, Goska; McGuffog, Lesley; Parsons, Michael T.; Simard, Jacques; Slager, Susan; Soucy, Penny; Easton, Douglas F.; Tischkowitz, Marc; Spurdle, Amanda B.; Schmutzler, Rita K.; Wappenschmidt, Barbara; Hahnen, Eric; Hooning, Maartje J.; Singer, Christian F.; Wagner, Gabriel; Thomassen, Mads; Pedersen, Inge Sokilde; Domchek, Susan M.; [...]

Association of germline variation with the survival of women with BRCA1/2 pathogenic variants and breast cancer

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  • Media type: E-Article
  • Title: Association of germline variation with the survival of women with BRCA1/2 pathogenic variants and breast cancer
  • Contributor: Muranen, Taru A.; Khan, Sofia; Fagerholm, Rainer; Aittomäki, Kristiina; Cunningham, Julie M.; Dennis, Joe; Leslie, Goska; McGuffog, Lesley; Parsons, Michael T.; Simard, Jacques; Slager, Susan; Soucy, Penny; Easton, Douglas F.; Tischkowitz, Marc; Spurdle, Amanda B.; Schmutzler, Rita K.; Wappenschmidt, Barbara; Hahnen, Eric; Hooning, Maartje J.; Singer, Christian F.; Wagner, Gabriel; Thomassen, Mads; Pedersen, Inge Sokilde; Domchek, Susan M.; [...]
  • imprint: Springer Science and Business Media LLC, 2020
  • Published in: npj Breast Cancer
  • Language: English
  • DOI: 10.1038/s41523-020-00185-6
  • ISSN: 2374-4677
  • Keywords: Pharmacology (medical) ; Radiology, Nuclear Medicine and imaging ; Oncology
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Germline genetic variation has been suggested to influence the survival of breast cancer patients independently of tumor pathology. We have studied survival associations of genetic variants in two etiologically unique groups of breast cancer patients, the carriers of germline pathogenic variants in <jats:italic>BRCA1</jats:italic> or <jats:italic>BRCA2</jats:italic> genes. We found that rs57025206 was significantly associated with the overall survival, predicting higher mortality of <jats:italic>BRCA1</jats:italic> carrier patients with estrogen receptor-negative breast cancer, with a hazard ratio 4.37 (95% confidence interval 3.03–6.30, <jats:italic>P</jats:italic> = 3.1 × 10<jats:sup>−9</jats:sup>). Multivariable analysis adjusted for tumor characteristics suggested that rs57025206 was an independent survival marker. In addition, our exploratory analyses suggest that the associations between genetic variants and breast cancer patient survival may depend on tumor biological subgroup and clinical patient characteristics.</jats:p>
  • Access State: Open Access